I've spent the last few weeks playing NLHE cash games at the Bellagio ($2-$5, $5-$10, $10-$20), Wynn ($2-$5) and Venetian ($2-$5). There is a discernible difference between $2-$5 and $5-$10, as there is between $5-$10 and $10-$20. There are structural differences within $2-$5 as well - Bellagio has a capped $500 buy-in, Venetian is capped at $1,000 while Wynn is uncapped. My current preference is the Venetian $2-$5 where I can buy in for 200BB and enjoy some semblance of deep stack play. The Bellagio $5-$10, with a capped buy-in of $1,000, is quite good as well, though my recently acquired disdain for 100BB-capped games may lead to my migration to the other uncapped $5-$10 games in town.
I played 2 sessions of $10-$20 at the Bellagio and felt a little out of place. I won both times, played some huge pots with the likes of Bellagio Jay, David Levi, Kenny Einiger, Doug Lee and other regulars, but still felt like a stranger.
Tommy Angelo describes one of the challenges of moving up in his Elements of Poker :
"You might not survive forever at the higher level. You might need to employ one of the vital skills for moving up, which is moving down."